Experimental corneal neovascularisation using sucralfate and basic fibroblast growth factor
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چکیده
منابع مشابه
Treatment of corneal epithelial wounds in dogs using basic fibroblast growth factor
An experimental study examined the effect of basic fibroblast growth factor (bFGF) on the healing of corneal epithelial wounds in dogs. A corneal wound was made on one eye from each of 40 dogs with a corneal trephine (6 mm diameter). Four concentrations of bFGF (0, 0.1, 0.5, and 1.0 μg/ml) were applied to the affected eyes three times daily. Fluorescein staining was used to assess the closure o...
متن کاملBasic fibroblast growth factor stimulates corneal endothelial cell growth and endothelial wound healing of human corneas.
PURPOSE To determine the dose response of human recombinant basic fibroblast growth factor (bFGF) on mitogenic activity, and the supplementary role of serum in cultured bovine and human corneal endothelial cells (BCECs, HCECs). To investigate the effect of bFGF on endothelial wound healing of human corneas in vitro. METHODS In cell culture, DNA synthesis was assessed by 3H-thymidine incorpora...
متن کاملToward surgical angiogenesis using slow-released basic fibroblast growth factor.
OBJECTIVE Therapeutic angiogenesis using basic fibroblast growth factor (bFGF) in coronary artery disease has been documented in a number of papers. However, the effectiveness is discrepant among documents. In this study, we evaluated the distribution of bFGF in the rat heart by different administration methods, and investigated the efficacy of slow-released administration of bFGF using biodegr...
متن کاملFibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate.
The study was designed to determine the gastroprotective and ulcer healing efficacy of basic transforming growth factor (bFGF) and to assess whether this peptide contributes to the action of sucralfate on the rat stomach. Application of human recombinant bFGF (1-100 micrograms/kg/hour subcutaneously) failed to affect the formation of acute gastric lesions induced by 100% ethanol and acidified a...
متن کاملThe mouse int-2 gene exhibits basic fibroblast growth factor activity in a basic fibroblast growth factor-responsive cell line.
The int-2 protein is related to basic fibroblast growth factor (bFGF) by amino acid sequence homology. To assess its biological activity, we constructed retroviral vectors containing four variants of mouse int-2 complementary DNA under the transcriptional control of the beta-actin promoter and tested their effects on human SW13 adrenal cortical tumor cells. This cell line specifically requires ...
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ژورنال
عنوان ژورنال: Australian and New Zealand Journal of Ophthalmology
سال: 1996
ISSN: 0814-9763,1440-1606
DOI: 10.1111/j.1442-9071.1996.tb01596.x